The Middle East has been the one region outside of Western Europe that American foreign policy and secretaries of state have been involved with since the Eisenhower administration. Sure, other regions have occupied the attention of Washington for an administration or even a decade or two: South East Asia from 1954 to 1975; Latin America and the Caribbean in the Kennedy administration, early Johnson administration and then again Central America during the Carter and Reagan administrations; Southern Africa from 1976 to 1989; and the Balkans in the 1990s. Now the Korean peninsula is a region of concern. But continuously throughout this period the Middle East has been of importance: as an arena for containment of the Soviet Union through regional alliances in the Eisenhower administration; mediating the Arab-Israeli conflict to reconcile contradictory national interests in the region from the Nixon administration through end of the second Bush administration; spreading democracy in the Bush administration and Obama administration.
The situation in the Israeli-Palestinian conflict is such that peace is not available in the near term. The Palestinians are divided between Hamas and Fatah, and so Fatah functions under the restraining influence of Hamas and cannot drastically modify its positions until Hamas is neutralized. This can be done either through defeat or merger. But merger or a national unity government is likely to be at the expense of any moderate tendencies in Fatah. In Israel the Center-Left is too weak to form a government without input from parties that are ideologically opposed to the two-state solution. Thus, we are left with the two parties to the conflict being dominated by political parties that are ideologically opposed to the two-state solution--or at least on terms that the other side can accept. This leaves Secretary of State John Kerry with solving the civil war in Syria as his main chance to make a mark in the region.